Research Experience

Research Projects

• Sep 2021 - Sep 2022 (1 year, 1 month)

  • Project title: "Investigating the link between dynein function, TDP-43 aggregation, and autophagy in ALS"
  • Location: University of Sussex

• Dec 2020 - Aug 2022 (1 year, 9 months)

  • Project title: "The effect of cytoplasmic dynein 1 dysfunction on neuromuscular junctions and protein aggregation in motor neurons"
  • Location: University of Sussex

• May 2020 – May 2023 (3 years)

  • Project title: "An exploratory analysis of the transcriptomic profile and alternative splicing of a TDP-43 mutant"
  • Location: University of Sussex

• May 2020 – Aug 2022 (2 years, 3 months)

  • Project title: "The role of cytoplasmic dynein 1 in the microglial response to lipopolysaccharide"
  • Location: University of Sussex

• Aug 2019 – Feb 2023 (3 years, 6 months)

  • Project title: "The effect of an ALS-linked TARDBP mutation on extracellular miRNAs from microglia"
  • Location: University of Sussex

• Apr 2019 – Jul 2019 (4 months)

  • Project title: "Imaging spontaneous calcium activity in the white matter"
  • Location: University of Sussex
  • Techniques used:
    • Cranial window surgery
    • Implantation of a cannula in the brain
    • Two-photon imaging in vivo

• Jan 2019 – Mar 2019 (3 months)

  • Project title: "Potential of inflammatory microglia as a source of extracellular microRNAs in amyotrophic lateral sclerosis"
  • Location: University of Sussex

• Sep 2018 – Dec 2018 (4 months)

  • Project title: "Investigating the effects of a synaptically-enriched glutamate reporter on basal AMPAR-mediated synaptic transmission"
  • Location: University of Sussex
  • Techniques used:
    • Whole-cell patch-clamp electrophysiology
    • Primary neuronal culture
    • Viral transduction
    • Programming

• Jan 2018 – Apr 2018 (4 months)

  • Project title: "Investigating the effects of intravenous catecholamines on heart rate and blood pressure under inhalational anaesthesia"
  • Location: University of Glasgow
  • Techniques used:
    • Inducing and maintaining general inhalational anaesthesia
    • Tracheostomy
    • Arterial and venous cannulation
    • Intravenous injections
    • Exposure and electrical stimulation of the cervical vagus nerve

• Sep 2017 – Dec 2017 (4 months)

  • Project title: "Investigating the therapeutic potential of angiotensin-(1-7) in a hypertensive model of stroke"
  • Location: University of Glasgow
  • Techniques used:
    • Histology
    • Analysis of MRI images